The present interview was conceived and realized for the occasion of the first 45 years of endless Physics Education Research activity of Professor Marisa Michelini, a lifetime dedicated to innovate teaching and learning environments to all degrees of instruction, and to design institutional architectures, where rooting these innovations. The interview structure is inspired to the nature of scientific thinking, i.e. inducing more general understanding from concrete observations, in two manners. First, the interview focuses on (ten) topics drawing from three box-cases about physics education research and teachers education in scientific areas: innovations in teaching/learning environments; theoretical and methodological frameworks; and strategies and tools for institutional cooperation between schools and governing bodies to urge policy making. Each topic is introduced by observations, from which the interview questions are induced. Second, each question draws from Marisa Michelini’s contributions, to touch core topics at the heart of science education, science and society.